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The Big Vitamin D Study Was Wrong – Supplements and Nutrition – Forums


VITAMIN D3 REALLY DOES WORK

That big vitamin D study funded by the government concluded that Vitamin D supplements don’t work. Here are all the things they got wrong.

A VERY QUESTIONABLE VITAMIN D STUDY

Conducting scientific studies like the following would probably be silly:

  • A study to test the efficacy of a new birth control pill using octogenarians as test subjects.
  • A study to test a new erection pill using the Unsullied, who’ve had both pillar and stones removed.
  • A study on the ability of fleece-lined thermal underwear to keep women who live in the Sonoran Desert warm.
  • A study to see if dogs really do love bacon, only using chipmunks instead of actual dogs.

If you used just a tiny bit of brain power, you could probably guess that any results obtained from such studies might not make much sense or have much applicability to anything.

Well, that’s pretty much how I feel about the big vitamin D study (VITAL) that just came out – the one that said that you don’t need to take vitamin D supplements (or even test levels of the vitamin) because they don’t help to protect bones from fractures or do much of anything else either.

Their study, titled “Supplemental Vitamin D and Incident Fractures in Midlife and Older Adults,” neglected to consider any number of extenuating factors that likely affected the results.

So, What Exactly Did the Study Say?

SO, WHAT EXACTLY DID THE STUDY SAY?

This-Vitamin-Flat-Out-Builds-Muscle

The study, published in the New England Journal of Medicine, involved roughly 26,000 generally healthy people in their 50’s or older. The aim of the randomized, controlled study (funded by the U.S. Government), known as VITAL, was to compare bone fractures in people who took a “high” dose of vitamin D3 (2,000 international units), n-3 fatty acids (1 gram per day), or a combination of both, for five years.

Taking vitamin D (or omega-3 fatty acids) didn’t appear to reduce the risk of broken hips or other bones. Neither did it seem to help prevent any major diseases. It also didn’t help prevent falls, reduce atrial fibrillation, change body comp, improve cognitive functioning, improve stroke outcomes, reduce frequency or severity of migraines, prevent macular degeneration, or reduce knee pain.

Their message, in an accompanying editorial, to the people who regularly supplement with vitamin D? Don’t bother.

Wow.

Now I’ve not spent a lot of time studying those aforementioned aspects of vitamin D supplementation. Instead, I’ve been more interested in its immunity-enhancing abilities, along with its role in athletic function, namely, skeletal muscle, lung function, heart function, and nervous system function, along with the possible role it plays in sexual function.

Regardless, I think they’re as wrong as a person or group of people can possibly be. They’re “We’ll never put a man on the moon” wrong.

Why my optimism in the face of such overwhelming statistics? Because the people who put together the study forget to consider a host of factors that determine whether vitamin D supplementation is effective or not.

Neglected Factor 1 – Magnesium

NEGLECTED FACTOR 1 – MAGNESIUM

The study didn’t address magnesium intake at all, and vitamin D, regardless of how much you take, won’t do the things you need it to do if you’re deficient in magnesium.

Vitamin D simply can’t be metabolized with out ample magnesium. With out it, the vitamin simply hangs round like some bum in entrance of a 7-Eleven.

Ordinarily, this magnesium difficulty won’t be that vital of an element, however on condition that roughly 80% of the American public appears to be poor within the mineral (based on the final NHANES research), it looks like it’s a very huge deal and will clarify why vitamin D3 supplementation didn’t seem to do squat within the VITAL research.

Oh, and athletes? They’re even worse off relating to magnesium, because the mineral is keen on leaving the physique in sweat.

When you actually need to work out if vitamin D is doing the issues it’s presupposed to do, you’ve additionally bought to watch magnesium consumption. This truth alone would possibly sink the veracity of the VITAL research.

Uncared for Issue 2 – Magnesium’s Buddy, Calcium

NEGLECTED FACTOR 2 – MAGNESIUM’S BUDDY, CALCIUM

Calcium and magnesium exist in a very tight relationship in the body. If this ratio isn’t respected, if something mucks it up – like a dramatic increase in the consumption of calcium foods without a concurrent increase in magnesium consumption – you get unfortunate consequences.

For one thing, you severely cripple the ability to transport, synthesize, and activate vitamin D.

Doctors and scientists see it all the time: Individuals with a high calcium to magnesium intake are at a higher risk of magnesium deficiency, and the activities of the three major enzymes that determine vitamin D concentrations are all magnesium dependent.

The result is a vitamin D deficiency, or at the very least, a vitamin D insufficiency.

So maybe you’re thinking, no problem, I’ll just double or triple-up my intake of vitamin D supplements. Not so fast.

The more vitamin D you take, the further you tap into magnesium stores, leaving you an increasingly insufficient amount to activate the enzymes responsible for determining vitamin D levels.

The problem is that calcium consumption, in-between the years 1977 to 2012 (the most recent dates for which we have data), increased at a rate 2 to 2.5 times that of magnesium intake, resulting in calcium to magnesium intake ratios of more than 3.0.

That’s understandable, given that the magnesium status is low in populations that consume a lot of processed foods that are high in fat, sugar, and refined grains.

The ideal ratio, however, is around 2.0 to 2.2, and anything higher than 2.8 can lead to problems, among them being the inability to metabolize vitamin D, not to mention a greater risk of developing type 2 diabetes, metabolic syndrome, chronic pulmonary disease, possibly some cancers, and impairing many of the 300 enzymatic reactions that involve magnesium.

Neglected Factor 3 – Fat Intake

NEGLECTED FACTOR 3 – FAT INTAKE

Vitamin D3 is fat soluble. Without concurrently ingesting some fat, taking a vitamin D3 capsule won’t do much at all.

This problem is demonstrated by one of the dairy industry’s practices. To comply with the wishes of their customers and well-meaning dietitians, dairy companies remove much of the fat from their products (for example, low-fat milk, skim milk, etc.). However, removing the fat also removes the fat-soluble vitamin D, so they fortify their products by adding back some vitamin D.

However, since the fortified product doesn’t contain much fat, the body fails to absorb appreciable amounts of it. The unabsorbed vitamin D is like the impoverished child pressing its nose against the windowpane, able only to watch in envy as all the other nutrients get absorbed into the toy store of the intestinal tract.

The same thing is likely to happen with taking vitamin D capsules. Without taking them with a fatty meal, they won’t get absorbed efficiently. Subsequently, researchers will assume that the vitamin didn’t work.

Neglected Factor 4 – Difficulty Elevating Vitamin D Levels

NEGLECTED FACTOR 4 – DIFFICULTY ELEVATING VITAMIN D LEVELS

How-to-Fix-the-Vitamin-D-Absorption-Problem

I’ve seen it repeatedly and even experienced it personally. You take the initiative and try to elevate your vitamin D levels to optimal blood levels and start popping conventional capsules and grimacing down sardines for weeks or even months, and nothing much happens. Levels don’t budge.

The trouble is, the total amount of vitamin D (both D2 and D3) found in a food during chemical analyses often doesn’t reflect its bioavailability. A lot of the vitamin is bound up in the actual food and remains so after you eat it. Lots of things contribute to this: the physiochemical form of the vitamin D, the fatty acids and fibers in the food, the size of the food particles themselves, and the quantity of the vitamin itself.

Interactions between vitamin D and other fat-soluble nutrients might also be a factor, as well as a bunch of host-related issues (age, disease state, fed condition, genetics, obesity, etc.).

Then there’s how you might prepare any vitamin-D-containing foods. Heat affects it. Light affects it. Moisture, oxygen exposure, and even storage conditions affect levels of vitamin D. That means that any vitamin-D-containing foods that are boiled, pressure-cooked, Insta-Potted, baked, or air fried could end up being vitamin-D compromised.

Sure, the VITAL study didn’t discuss food sources of vitamin D, but traditional vitamin D supplements are prone to all the same manufacturing and absorption problems attributed to vitamin-D-containing foods – moisture, oxygen exposure, excess heat, and non-optimal storage conditions in general.

Unless all the above-listed precautions were taken in preparing and distributing the vitamin D used in the study, there’s sufficient reason to think that the capsules they used were the 3.2 beer of the vitamin D world. In other words, you’d need to ingest more than usual to get a vitamin D “buzz,” i.e., a protective effect.

What They Should Have Used Instead

WHAT THEY SHOULD HAVE USED INSTEAD

The only form of vitamin D currently worth taking is microencapsulated vitamin D3. This type of the vitamin is manufactured by encapsulating vitamin D molecules in liposomes, or strong lipid nanoparticles.

The vitamin then presents as tiny “beadlets” and is protected against moisture, oxidation, pH, temperature, and mechanical forces. The microencapsulated product is secure, water dispersible, and, most significantly, extremely bioavailable.

Research present that the consequences of this type of vitamin D stay fixed for as much as 14 days, making it clearly superior to the traditional vitamin D dietary supplements that comprise a lot of the market. Individuals who use it have reported fast and spectacular will increase in blood ranges of vitamin D.

Nevertheless, as careworn above, you continue to have to have sufficient ranges of magnesium for it, or any type of vitamin D, to work. Given how troublesome it’s to acquire and preserve sufficient ranges of magnesium via food regimen alone, it appears prudent to pop not less than 400 mg. a day, ideally in chelated form.
I-Well

My Closing Argument

MY CLOSING ARGUMENT

I’m still dumbstruck at how the VITAL study seemed to totally ignore the vast amounts of research on vitamin D and immunity, let alone all its positive effects on health and performance.

The simple fact is that infection-fighting T cells need vitamin D to activate. Researcher Carsten Geisler explained it this way:

“When a T cell is exposed to a foreign pathogen, it extends a signaling device or ‘antenna’ known as a vitamin D receptor, with which it searches for vitamin D. This means the T cells must have vitamin D or activation of the cell will cease.”

There’s also strong epidemiological evidence that people who live closer to the equator generally have fewer incidences of disease and better prognoses when they do get sick than people who live farther away from the equator. That’s because exposure to sunlight prods the body into making more vitamin D.

Further, assorted studies point to the strong possibility that once your vitamin D levels get beyond, say, around 50 mg per ml of blood (“normal” is considered to be around 20 mg per ml.), you’re practically immune to certain viruses.

I might go on for pages, however to scale back my argument to the only phrases doable, our immune system wants vitamin D to perform correctly, and there are at the moment too many obstacles for folks to get the quantity they want.

So for those who actually need to conduct a top quality research that assessments the efficacy of vitamin D dietary supplements, you’ve bought to consider all of the components I discussed, not simply toss them out into the world like big handfuls of rooster feed.

References

REFERENCES

  1. Autier P et al. Vitamin D Supplementation and Total Mortality: A Meta-analysis of Randomized Controlled Trials. Arch Intern Med. 2007 Sep 10;167(16):1730-7. PubMed.
  2. Dai Q et al. Magnesium standing and supplementation affect vitamin D standing and metabolism: outcomes from a randomized trial. Am J Clin Nutr. 2018 Dec 1;108(6):1249-1258. PubMed.
  3. Dawson-Hughes B et al. Meal situations have an effect on the absorption of supplemental vitamin D3 however not the plasma 25-hydroxyvitamin D response to supplementation. J Bone Miner Res. 2013 Aug;28(8);1778-83. PubMed.
  4. Ginde AA et al. Affiliation Between Serum 25-Hydroxyvitamin D Stage and Higher Respiratory Tract An infection within the Third Nationwide Well being and Vitamin Examination Survey. Arch Intern Med. 2009 Feb 23;169(4):384-90. PubMed.
  5. Leitch BA et al. Vitamin D Consciousness and Consumption in Collegiate Athletes. J Power Cond Res. 2021 Oct 1;35(10):2742-2748. PubMed.
  6. Maurya VK et al. Vitamin D microencapsulation and fortification: Developments and applied sciences. J Steroid Biochem Mol Biol. 2020 Feb;196:105489. PubMed.
  7. Marineua AR et al. Vitamin D supplementation to forestall acute respiratory tract infections: systematic evaluation and meta-analysis of particular person participant information. BMJ. 2017 Feb 15;356:i6583. PubMed.
  8. Rosanoff A et al. Important Nutrient Interactions: Does Low or Suboptimal Magnesium Standing Work together with Vitamin D and/or Calcium Standing? Adv Nutr. 2016 Jan 15;7(1):25-43. PubMed.
  9. Šimoliūnas E et al. Bioavailability of Totally different Vitamin D Oral Dietary supplements in Laboratory Animal Mannequin. Medicina (Kaunas). 2019 Jun 10;55(6):265. PubMed.
  10. Maurya VK et al. Vitamin D microencapsulation and fortification: Developments and applied sciences. J Steroid Biochem Mol Biol. 2020 Feb;196:105489. PubMed.
  11. Šimoliūnas E et al. Bioavailability of Totally different Vitamin D Oral Dietary supplements in Laboratory Animal Mannequin. Medicina (Kaunas). 2019 Jun 10;55(6):265. PubMed.
  12. Urashima M et al. Randomized trial of vitamin D supplementation to forestall seasonal influenza A in schoolchildren. Am J Clin Nutr. 2010 Could;91(5):1255-60. PubMed.





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